POPULATION BASED COHORT STUDY ON THE ASSOCIATION BETWEEN MATERNAL EXPOSURE TO PM2.5 OR LESS DURING PREGNANCY AND FOETAL CONGENITAL ANOMALIES IN KANPUR, INDIA

Anindita Bhattacharya and Dr. Alka Tangri*

ABSTRACT

Few studies from western countries have linked prenatal exposure to ambient particulate matter < 2.5 μm (PM2.5) with increased risk of congenital anomalies. However, the results are mixed. Particularly, evidence is limited for Indian pregnant women. In this retrospective cohort study, we matched the data of all pregnant women laboured in public hospitals during 2020–2022 in Kanpur city and the data of daily average PM2.5, nitrogen dioxide (NO2), sulphur dioxide (SO2) and ozone (O3) concentrations of the nearest monitor station. We calculated a time-dependent exposure over the entire pregnancy for each woman. We used a time varying Cox proportional hazards model to explore the association between PM2.5 exposure and the risk of congenital anomalies, after adjusting for individual confounders and other pollutants. A total of 5000 singleton live births were included in the study, and 530 (1.35%) were with congenital anomalies. An increase of 10 μg/m3 in PM2.5 exposure over the entire pregnancy was significantly associated with increased risk of congenital anomalies, with hazard ratio (HR) of 1.35 [95% confidence interval (95%CI): 1.16, 1.58]. For subtype analyses, PM2.5 exposure exhibited a significant association with cardiac anomalies and other unclassifiable anomalies, with HRs of 1.60 (95%CI: 1.24, 2.08) and 1.42 (95%CI: 1.07, 1.89), respectively. The impacts of PM2.5 exposure on or facial anomalies and musculoskeletal anomalies were not significant. The results indicate high concentration of PM2.5 could increase the risk of congenital anomalies especially for cardiac anomalies. Self-protective measures involving reducing PM2.5 pollution exposure during pregnancy as well as environmental policies aiming to restrict PM2.5 emission could be helpful to reduce the burden of cognitional anomalies.

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