EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TOPIROXOSTAT IN BULK AND PHARMACEUTICAL DOSAGE FORM

Pallavi Suthar* and Manali Ram

ABSTRACT

A simple, sensitive, rapid, accurate, reproducible and less time consuming UV visible spectroscopic method has been developed for the determination of topiroxostat in bulk and tablet dosage form. The wavelength maxima for topiroxostat was found to be 320.0nm. Beer’s law was obeyed in the concentration range of 10-50μg/ml. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 3μg/ml and 9.27μg/ml. The percentage recovery of the drug for the proposed method was 99.63% indicating no interference of tablet excipients. The results demonstrate that proposed method is accurate, precise and reproducible while being simple and rapid too for determination of topiroxostat in tablet dosage form.

Keywords: Validation, Range, Concentration, Method development, Percentage recovery.

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