COMPARATIVE EVALUATION OF INHIBITORY EFFECT OF BLUE-M ORAL GEL VERSUS HEXIGEL ON PORPHYROMONAS GINGIVALIS: AN IN-VITRO STUDY

Dr. Padmaja Patil*, Dr. Simran Kaur Makhija, Dr. Surkeha Bhedasgaonkar, Dr. Janak Kapadia, Dr. Ravikumar Jirali and Dr. Harsha Waswade

ABSTRACT

Introduction: Periodontitis is a multifactorial chronic inflammatory disease associated with altered dental biofilm that causes progressive destruction of supporting tissues of teeth where microorganisms play crucial role. Among these Porphyromonas gingivalis is major Gram-negative anaerobic bacterium involved in pathogenesis of periodontitis, which has numerous virulence factors. Traditionally, this disease is treated with basic periodontal procedures along with the use of chlorhexidine digluconate. Oxygen is essential nutrient for multiple processes including oxidative killing of bacteria, re-epithelialization, angiogenesis, and collagen synthesis. Recently, new product that releases oxygen has been introduced. Considering these characteristics, Blue – M Oral gel is compared with Hexigel to evaluate the beneficial effects on periopathogens. Objective: To compare inhibitory effects of Blue – M Oral gel and Hexigel against Porphyromonas gingivalis. Methodology: In this in- vitro study, the inhibitory effects of Blue – M Oral gel will be studied on P. gingivalis culture and compared to Hexigel and distilled water by using agar disc diffusion method. After incubation, diameter of halos of inhibition of bacterial growth around the paper discs will be measured and compared. Results: The intergroup comparison of antimicrobial effects of Blue M Oral Gel and Hexigel against P. gingivalis showed a statistically highly significant (p value < 0.001). Conclusion: Hexigel acts effectively against P. gingivalis, hence remains to be the gold standard while Blue -M oral gel is not effective antimicrobial agent within the limitations of study.

Keywords: Blue -M oral gel, Hexigel, P. gingivalis, Antimicrobial effect.