EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A STUDY ON THE EFFECT OF ARSENIC ON TISSUE HISTOLOGY AND ITS DEPOSITION PATTERN IN VARIOUS ORGANS OF WISTAR ALBINO RAT

Dil Umme Salma Chowdhury, Saiful Islam, Rasheda Akter, Laila Khaleda, Zillur Rahman, Mohammad Al-Forkan*

ABSTRACT

A clear and better knowledge on the effect of arsenic in hepatic, renal, splenic and cardiac tissue is required to understand the mechanism of arsenic toxicity. Our study was carried out to evaluate the arsenic-induced histological alterations observed in liver, kidney, spleen and heart of Wistar albino rats along with some hematological, biochemical and microscopic parameters. Wistar albino female rats were divided into four groups and treated as follows: Group 1: control, 2: arsenic (sodium arsenite: 50 ppm; 28 days), 3: arsenic (sodium arsenite: 100 ppm; 28 days), 4: arsenic (sodium arsenite: 150 ppm; 28 days). We found immunosuppression, leukopenia as well as marked increase in serum ALT and AST of arsenic intoxicated rats. Moreover, sodium arsenite produced marked necrosis in kidney of rats, whereas in heart mild muscle necrosis was observed. In case of spleen, moderately enlarged white pulp was seen. Besides, we also have found that liver and spleen accumulated more arsenic than kidney and heart. We believe that in order to know more extensively the toxic effects of arsenic, the findings of our study in animal model will become useful.

Keywords: Arsenic, histopathology, hematology, Wistar rat.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )