DISULFIRAM INDUCED PSYCHOSIS
Archana Rajan*, Alwy Joseph, Swetha Reba Mathews and Sunil Antony
Disulfiram is a drug of choice in alcohol dependence. It has been used for more than 65 years. Disulfiram produces its action by altering the normal metabolism of alcohol. There are various adverse drug reactions (ADR) associated with disulfiram use. Among which, psychosis is a major one. The mechanism of ADR is the inhibition of Dopamine Beta Hydroxylase (DBH). Patients receiving disulfiram must be sensitized regarding the possible ADR.
Keywords: Disulfiram, Alcohol dependence, DBH, Psychosis.
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