FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING GLIBENCLAMIDE
Santosh Girani*, Dhaval Patel, Mantesh Kavatekar, Ajay Shahapur and Vital Vijapure
The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Glibenclamide with different ratios of polymeric (Eudragit RS100, Ethyl cellulose, Hydroxypropyl Mehyl cellulose) systems by the solvent evaporation technique by using 30% w/w of di-butyl phthalate to the polymer weight, incorporated as plasticizer. The physicochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility. Formulated transdermal films were physically evaluated with regard to thickness, weight variation, drug content, folding endurance moisture. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. It shown that drug release follows zero order and the mechanism of release is diffusion from the polymer.
Keywords: Glibenclamide, Eudragit RS100, Ethyl cellulose, Hydroxypropyl Mehyl cellulose, Transdermal Film. In-vitro permeation study.
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