EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

INVESTIGATION OF ANTI-SPASMODIC POTENTIAL OF CLEOME GYNANDRA ON ISOLATED CHICKEN INTESTINE

Sathya B.*, Rajesh M., Renuka M. and Rukshana Begum N.

ABSTRACT

The present study was aimed to investigate the anti-spasmodic effect of Cleome gynandra leaves of the family Cleomaceae on isolated chicken ileum by an in vitro pharmacological assay. Cleome gynandra is richly obtainable throughout India with countless hidden therapeutic values. It is used in traditional system for epilepsy, protozoal and worm infections, irritable bowel syndrome and as an antioxidant. The spasm was induced by acetycholine, the spasmogen. The ethanolic extract of Cleome gynandra leaves was prepared by simple maceration. Anti-spasmodic activity was assessed by antagonistic method of bioassay on chicken ileum using Tyrode as physiological salt solution. Effects of acetylcholine and acetylcholine followed by ethanolic leaves extract were studied on isolated chicken ileum and compared with atropine, the standard anti-spasmodic agent. The extract revealed marked decrease in acetylcholine induced spasm (the cholinolytic like effect) on chicken ileum induced by acetylcholine. Action of flavanoids and steroids on M3 receptors in the chicken ileum granted to the effect. In conclusion, the ethanolic extract of leaves of Cleome gynandra plant manifested optimistic antispasmodic action on chicken ileum.

Keywords: Acetylcholine, Atropine, Anti-spasmodic, Cleome gynandra, Chicken ileum.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia