EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

PHAMACOGNOSTICAL ANALYSIS AND INVIVO ANTILITHIATIC ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF CANAVALIA GLADIATE AGAINST ETHYLENE GLYCOL INDUCED LITHIASIS IN WISTAR RATS

G. Nalini*, N. Chidambaranathan, T. Manibharathi, K. Marikrishnaa and G. N. Rishi.

ABSTRACT

The objective of the study is to investigate pharmacognostical analysis & antiurolithiatic activity of Hydroalcoholic extract of Cannavalia Gladiata. Pharmacognostic study include determination of physiochemical, fluorescence analysis & phytochemical screening of cannavalia gladiate. For antilithiatic study, 30 male wistar rats were segregated into 5 groups. All groups receive 1% Ethylene glycol for 28 days except normal control. G1(Normal control) receive normal diet and water, G2 (Toxic control) receive only ethylene glycol, G3(Standard) treated with Cystone at 100mg/kg whereas G4 & G5 treated with 200 & 400mg/kg of Hydroalcoholic extract of Cannavalia gladiata. After 28 days, various parameter like calcium, phosphate, magnesium, oxalate, protein, uric acid and creatinine concentration were estimated using Serum & Urine analysis by standard methods. Histopathological studies were carried out using Kidney section. Treatment with Hydroalcoholic extract of Canavalia gladiate at 200 and 400 mg/kg significantly reduced the serum & urinary levels of protein, uric acid, calcium, phosphate, oxalate & creatinine in dose dependent manner along with significant increase in magnesium. The histopathological examinations revealed that deposition of calcium oxalate crystals in renal tubules and glomerular congestion were reduced after HAECG treatment. This study demonstrate that Hydroalcoholic extract of Cannavalia gladiate reduces and inhibits the growth of urinary stones showed potent antiurolithiatic activity.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia