FORMULATION AND EVALUATION OF BUCCAL PASTE CONTAINING MELAMPODIUM DIVARICATUM AGAINST MOUTH ULCER

*Rajana A. and Dhanya V. O.

ABSTRACT

Buccal formulations is a medicine given between the gum and the inner lining of the mouth cheek. Buccal paste is the medication used for the relief of symptoms of mouth ulcer. Melampodium extract usually used to govern several diseases such as dental carries, malaria and possess antileishmanial, antibacterial, anti-inflammatory and antinociceptive activity. Melampodium comprises some essential phytoconstituents such as sesquiterpenes, E-caryophyllenes, Germacrene. The plant extract was characterized by decoction process. The present research has been undertaken with the aim to formulate and evaluate the buccal paste containing aqueous extract of flower buds of Melampodium divaricatum against mouth ulcer. Paste formulation was designed using accurately weighed amount of drug extract along with other additives such as sodium CMC, starch, methyl paraben, propyl paraben, white soft paraffin etc. Formulations were evaluated for following parameters such as pH, spreadability, homogeneity, viscosity, extrudability, anti –bacterial activity and in-vitro drug release. The formulation was finalized through optimization by central composite design. The result showed that the optimized herbal oral formulation containing Melampodium divaricatum extract shows that all physicochemical parameters were found to be compactable with the normal range. Anti-bacterial study of formulation revealed excellent efficacy against mouth ulcer. Herbal buccal paste was formulated which was stable and effective for the treatment of mouth ulcer.

Keywords: Melampodium divaricatum, buccal paste, mouth ulcer.