EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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Abstract

FORMULATION AND EVALUATION OF BUCCAL PASTE CONTAINING MELAMPODIUM DIVARICATUM AGAINST MOUTH ULCER

*Rajana A. and Dhanya V. O.

ABSTRACT

Buccal formulations is a medicine given between the gum and the inner lining of the mouth cheek. Buccal paste is the medication used for the relief of symptoms of mouth ulcer. Melampodium extract usually used to govern several diseases such as dental carries, malaria and possess antileishmanial, antibacterial, anti-inflammatory and antinociceptive activity. Melampodium comprises some essential phytoconstituents such as sesquiterpenes, E-caryophyllenes, Germacrene. The plant extract was characterized by decoction process. The present research has been undertaken with the aim to formulate and evaluate the buccal paste containing aqueous extract of flower buds of Melampodium divaricatum against mouth ulcer. Paste formulation was designed using accurately weighed amount of drug extract along with other additives such as sodium CMC, starch, methyl paraben, propyl paraben, white soft paraffin etc. Formulations were evaluated for following parameters such as pH, spreadability, homogeneity, viscosity, extrudability, anti –bacterial activity and in-vitro drug release. The formulation was finalized through optimization by central composite design. The result showed that the optimized herbal oral formulation containing Melampodium divaricatum extract shows that all physicochemical parameters were found to be compactable with the normal range. Anti-bacterial study of formulation revealed excellent efficacy against mouth ulcer. Herbal buccal paste was formulated which was stable and effective for the treatment of mouth ulcer.

Keywords: Melampodium divaricatum, buccal paste, mouth ulcer.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia