STUDIES ON EFFECT OF ALOEVERA GEL ON THE RELEASE PROFILE OF DICLOFENAC POTASSIUM FROM DIFFERENT FORMULATIONS

Shilpa E. K.* and Suja C.

ABSTRACT

A sustained release formulation is one which delivers the drug slowly and continuously for an extended period of time. Diclofenac Potassium is a non-steroidal anti-inflammatory agent with short half life and undergoes first pass metabolism with a bioavailability of 50%, hence suitable for developing sustained release formulation. From the review of literature, it was found that aloevera gel powder is a potential drug release retardant. The aim of this research work was to formulate an optimized sustained release tablet of Diclofenac Potassium using aloevera gel powder as the release retardant. The formulations were designed as suggested by the design expert software (version 13, Stat- Ease) using aloevera gel powder (AGP) & hydroxyl propyl methyl cellulose(HPMC) as the release retardants along with other excipients by direct compression method. The formulated tablets were of uniform weight and drug content. The pharmaceutical properties of all formulations and their invitro drug release were evaluated. The optimized formulation, F6 showed a drug release of 100% at the end of 12 hours & followed first order kinetics with non fickian release pattern. From the drug release profile, it was observed that aloevera gel powder had a retardant effect. Hence it can be concluded that aloevera gel powder is a potential and economical drug release retardant for the development of sustained release dosage form.

Keywords: Aloevera gel powder, Diclofenac potassium, Sustained release tablet.