( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Rahana Raveendran* and Ambili M. V.


Lipospheres are lipid-based dispersion systems in which drug is dispersed in lipidic core, the surface of which is embedded with emulsifier layer. Particle size of such lipid particles ranges from 0.2-100 micrometer. Nifedipine (NI) is a high potent calcium channel blocker, used for the treatment of Hypertension & angina, is poorly soluble and undergo extensive first pass metabolism, which lead to poor bioavailability (about 50%). The aim of the research work is to develop the optimized formulation of PEGylated Nifedipine liposphere with a goal of improving the solubility and giving a prolonged release of drug. Nifedipine liposphere were prepared by melt dispersion techniques using stearic acid, and paraffin wax as lipid matrix and PEG 4000(Poly Ethylene Glycol) as surfactants. Formulation was optimized by using Central composite design where particle size, entrapment efficiency and drug release were dependent variables and lipid and surfactant concentration were independent variables. Optimized formulation of nifedipine shows 95.33% entrapment efficiency and particle size was found to be 77.72 μm with spherical shaped. In vitro release was carried out using dissolution apparatus in phosphate buffer and optimized formulation shows 95.23% drug release within 12 hrs which follows non-fickian type of transport. Developed liposphere formulation was able to sustain the drug release and entrap the nifedipine at high level. The findings of this study suggest that issue of nifedipine stability and poor solubility can be remedied by tactical engineering of lipid drug delivery systems such as liposphere.

Keywords: Nifedipine, Liposphere, Drug release, Poly ethylene glycol.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia