( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Swathi Krishna C.* and Sujith S. Nair


Proniosome are microscopic lamellar structure, they combine a non-ionic surfactant and cholesterol followed by hydration in aqueous media. Diacerein is NSAID with short half-life 4hr and undergo first pass metabolism such that only 35-56% of administered dose reaches systemically. The primary objective of the research is to create a proniosomal gel that enhances transdermal delivery and improves drug availability, by using a Central composite design to statistically optimize the formulation. The goal is to investigate how the addition of non-ionic surfactant and cholesterol can increase drug entrapment and release. The proniosomal gel containing Diacerein was made through a coacervation phase separation method using Span 60, cholesterol, and other ingredients. By using the central composite design, the impact of the components on the physicochemical properties of the proniosomes was examined, and the best formulation was identified. The findings showed that the optimal combination of surfactant and cholesterol resulted in high-quality proniosomes with sustained drug release. The optimal cholesterol and span 60 content level were determined to be 1860.761mg and 309.693mg, with a maximum desirability value 0.969. The entrapment efficiency, % drug release and vesicle size of the optimized formulation was found to be 95.3998%, 96.8901% and 5.5752 respectively. This study has demonstrated that the problem of poor Diacerein absorption can be resolved through the use of the proniosomal gel formulation. Furthermore, the concentration of both cholesterol and the non-ionic surfactant was found to be highly significant in terms of enhancing drug entrapment efficiency and drug release.

Keywords: Diacerein, proniosomal gel, span 60, cholesterol.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia