DESIGN AND EVALUATION OF DIACEREIN PRONIOSOMAL GEL FOR ENHANCED TOPICAL DELIVERY
Swathi Krishna C.* and Sujith S. Nair
Proniosome are microscopic lamellar structure, they combine a non-ionic surfactant and cholesterol followed by hydration in aqueous media. Diacerein is NSAID with short half-life 4hr and undergo first pass metabolism such that only 35-56% of administered dose reaches systemically. The primary objective of the research is to create a proniosomal gel that enhances transdermal delivery and improves drug availability, by using a Central composite design to statistically optimize the formulation. The goal is to investigate how the addition of non-ionic surfactant and cholesterol can increase drug entrapment and release. The proniosomal gel containing Diacerein was made through a coacervation phase separation method using Span 60, cholesterol, and other ingredients. By using the central composite design, the impact of the components on the physicochemical properties of the proniosomes was examined, and the best formulation was identified. The findings showed that the optimal combination of surfactant and cholesterol resulted in high-quality proniosomes with sustained drug release. The optimal cholesterol and span 60 content level were determined to be 1860.761mg and 309.693mg, with a maximum desirability value 0.969. The entrapment efficiency, % drug release and vesicle size of the optimized formulation was found to be 95.3998%, 96.8901% and 5.5752 respectively. This study has demonstrated that the problem of poor Diacerein absorption can be resolved through the use of the proniosomal gel formulation. Furthermore, the concentration of both cholesterol and the non-ionic surfactant was found to be highly significant in terms of enhancing drug entrapment efficiency and drug release.
Keywords: Diacerein, proniosomal gel, span 60, cholesterol.
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