EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

AN OVERVIEW ON COVID-19 INDUCED AVASCULAR HIP NECROSIS

Dr. Vankodoth Sireesha*, M. Pratibha, M. Sunil Kumar, CH. Kanna Reddy and R. Lavanya

ABSTRACT

COVID-19 adversely impacts a number of human body systems as a part of ‗long COVID-19, such as Guillain-Barré syndrome, lung fibrosis, pulmonary thromboembolism, cardiomyopathy, and sensory dysfunction, one of which is Avascular Necrosis. The purpose of this article is to review AVN as a long-term sequel to COVID-19 by describing an overview of pathogenesis, diagnosis, and management. Avascular necrosis (AVN) is a degenerative bone condition characterized by cellular death and bone collapse from compromised subchondral blood circulation. Vascular disruption, hypertension, intravascular occlusion, or extravascular impingement all contribute to the onset of AVN by decreasing bone circulation. AVN can be caused by a variety of conditions, but the most frequent predisposing factor for AVN is corticosteroids used in the management of COVID-19. Although the pathogenesis of steroid-induced AVN is not fully understood, several hypothesized mechanisms have been put forth, including abnormalities in bone marrow stem cells, vascular endothelial dysfunction, fat emboli, fat hypertrophy, and a hypercoagulable state. The breakdown of vascular function and the emergence of bone necrosis are caused by the interaction of a hyperinflammatory and hypercoagulable condition. Along with a comprehensive medical history and physical examination, the diagnosis can be verified by performing one of the following tests: X-ray, CT, MRI, bone scan, biopsy, and bone functionality assessment. The goals of treatment for AVN include reducing pain, slowing the disease's progression, avoiding collapse, and restoring joint function, which are achieved by using medications, surgical procedures, and lifestyle modifications.

Keywords: Avascular necrosis, Covid-19, Corticosteroids, Bone Necrosis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia