A REVIEW ON NANOSPONGES: AN ASCENDANCE OF POTENTIAL NANOCARRIER FOR EMERGING DRUG DELIVERY

Falgun A. Dabhi*, Vrushti D. Shah and Bhavin D. Pandya

ABSTRACT

The targeted delivery of drug molecule is been always strenuous. This can be accomplished through the specialized drug delivery system without affecting the efficacy and quality of the drug. With the advancement of nanotechnology and to overcome this problem “Nanosponge” has been developed. Few new drugs cannot be effectively delivered in a conventional dosage form. Nanoparticles are fragments in the 1 – 100 nm range. These nanoparticles are used in polymeric nanoparticles, nanosponges, nano-emulsions, carbon emulsion tubes, etc. Nanosponge is a nanosized particle of virus sized filled with a variety of drugs. Nanosponge is formulated by crosslinking cyclodextrin with cross polymers. It is used to control the release rate of drug delivery. These tiny sponges circulate into the body until they encounter the target site and stick on the surface and initiate to release of drugs in a predictable manner. It also helps to overcome certain problems like poor bioavailability, and drug toxicity, decrease side effects, etc. another characteristic of nanosponges is their aqueous solubility. Due to its porous structure, helps to entrap the various drug molecule into it. Nanosponges are delivered in various forms such as oral administration, topical administration, and parental administration. Nanosponges are synthesized by various methods like emulsion solvent diffusion method, ultrasound-assisted method, solvent method etc. Nanosponge drug delivering system has evolved as one of the most prominent fields used in cancer therapy, protein drug delivering, used as adsorbent for poison etc.

Keywords: Targeted delivery, Nanosponge, Nanoparticle, Porous, Cancer therapy.