ANTI-DIABETIC EFFECT OF HYDROALCOHOLIC EXTRACT OF NYMPHAEA PUBESCENS ENTIRE PLANT IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS
The present study explores the anti-diabetic activity of a hydroalcoholic extract of the entire Nymphaea pubescens (NP) plant in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetic Wistar rats had to take Metformin (10 mg/kg body weight) and NP hydroalcoholic extract (250 and 500 mg/kg body weight) orally for 21 days. Further, changes in the blood glucose level (BGL), body weight (BW), and biochemical parameters such as total protein (TP), serum creatinine (SC), serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SGOT) had observed. Pancreatic histology revealed that β-cells regeneration in islets of Langerhans.
Keywords: Nymphaea pubescens, Anti-diabetic activity, Streptozotocin, and Metformin.
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