EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

ANTI-DIABETIC EFFECT OF HYDROALCOHOLIC EXTRACT OF NYMPHAEA PUBESCENS ENTIRE PLANT IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

Gaddam Sushma*

ABSTRACT

The present study explores the anti-diabetic activity of a hydroalcoholic extract of the entire Nymphaea pubescens (NP) plant in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetic Wistar rats had to take Metformin (10 mg/kg body weight) and NP hydroalcoholic extract (250 and 500 mg/kg body weight) orally for 21 days. Further, changes in the blood glucose level (BGL), body weight (BW), and biochemical parameters such as total protein (TP), serum creatinine (SC), serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SGOT) had observed. Pancreatic histology revealed that β-cells regeneration in islets of Langerhans.

Keywords: Nymphaea pubescens, Anti-diabetic activity, Streptozotocin, and Metformin.


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SJIF Impact Factor: 7.065

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