EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

CYTOKINE PROFILE OF PATIENTS WITH ENT DISEASES ON THE BACKGROUND OF COVID-19

Amonov Erkin I. and Musakhodjaeva Diloram A.

ABSTRACT

Patients with COVID-19 are characterized by the development of a "cytokine storm" - a state of uncontrolled release of a large number of inflammatory mediators. The aim of the study was to assess the levels of regulatory cytokines in the blood serum of patients with ENT diseases in hospitalized patients with moderate and severe severity of COVID-19. Material and methods. 84 patients with a confirmed diagnosis of coronavirus infection were under observation. Of these, 16 (19.04%) patients had a mild course, 44 (52.4%) patients with a moderate degree, and 24 (28.6%) patients with a severe degree. The diagnosis of COVID-19 was established based on the detection of SARS-CoV-2 RNA by PCR in swabs from the nasopharynx and oropharynx. The levels of serum cytokines (IL-1β, IL-4, IL-6, IFNα and IFNγ) were studied by ELISA using the kits of Vector Best JSC (Novosibirsk, Russia). The results of the study showed that the levels of both pro-inflammatory cytokines (IL-1β and IL-6) and anti-inflammatory (IL-4) cytokine in patients with ENT diseases on the background of COVID-19 are sharply increased. Moreover, the elevated level is more pronounced in severe COVID-19. Interferons in COVID-19 have multidirectional synthesis: IFNα is reduced, and IFNγ is increased. Therefore, the cytokine storm in COVID-19 is a severe clinical condition caused by systemic hyperinflammation.

Keywords: Patients with ENT diseases, COVID-19, cytokines.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 May 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: MAY ISSUE PUBLISHED

    MAY 2024 issue has been successfully launched on MAY 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia