EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A COMPARITIVE STUDY OF PRE AND POST TREATMENT ECG AND ECHO FINDINGS IN ACUTE EXACERBATION OF COPD PATIENTS

Muthukumaran, Manu Mohan, *Tom Devasia, Aswini Kumar Mohapatra and Ashok Kumar Y G.

ABSTRACT

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by progressive airflow limitation. COPD is associated with significant comorbidities like cardiac disease which is common. COPD patients experience frequent exacerbations which mitigate change in existing management. Pulmonary artery hypertension is common in COPD. This study was conducted to assess the changes in Electrocardiogram (ECG) and Echocardiogram pre and post exacerbation of COPD. COPD males with age more than 40 years without significant comorbidities who were admitted due to exacerbation were included in the study. ECG and Echocardiogram was performed at the baseline and on one month of follow up. Spirometry was performed at the baseline when patients were stabilized. 108 patients were included in this study. Majority of our patients were of grade III (severe) (46.3%) and grade IV COPD (very severe) (38.8%) classes based on post bronchodilator FEV1% on spirometry as per GOLD criteria. We could not find any significant changes in ECG, pre and post exacerbation of COPD, except normalization of sinus tachycardia. At baseline, mild PAH was observed in 88 patients(81.48%) with mean RVSP=38.59mmHg,moderate PAH was observed in 17 patients(15.74%) with mean RVSP=52.47 mmHg and severe PAH was observed in 3 patients (2.77%) with mean RVSP=70.33mmHg. While correlating spirometry with RVSP at the baseline, mild PAH was common in grade III (51.13%), whereas severe PAH were common in grade III and grade IV COPD (64.7 & 100% respectively). We found statistically significant decrease in right ventricular systolic pressure (RVSP) following treatment of exacerbation of COPD. Echocardiography screening of COPD patients is beneficial to assess the pulmonary artery pressure and identify patients with severe pulmonary artery hypertension, who may benefit with additional medications including phosphodiesterase inhibitors for those with severe PAH.

Keywords: spirometry, phosphodiesterase, COPD.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )