EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

SCANNING ELECTRON MICROSCOPIC STUDY OF KIDNEYS OF DIABETIC NON-CALCULOGENIC RATS ON DIFFERENT DIETS

Dr. Dhanalekshmy T. G.*

ABSTRACT

Urolithiasis is a painful urinary disorder that results in the excretion of tiny crystals in the urine. Kidney stones contain commonly, calcium in combination with phosphate or oxalate. Diet plays an important role in the pathogenesis of kidney stones as dietary ingredients is understood to influence the solute concentration of urine. The experimental work was done in wistar rats to study the morphology of the crystals seen in the sections of kidney of diabetic non calculogenic rats fed on different diets under Scanning Electron Microscope to understand whether these diets aggravate calculogenesis. Diabetes mellitus was induced in the experimental rats with alloxan monohydrate. Rats were fed on diet low in vitamin A and high in vitamin C for three months. At the end of the experiment, the kidneys were excised and fixed and later studied under different magnification power in the JEOL JSM-5600 LV SEM to understand the morphology of the crystals seen in these tissues. At magnification x170, kidneys of the diabetic non-calculogenic rats on high vitamin C diet showed approximately 3-4 crystals/field. The crystals were polymorphic. At x1300, single large crystals were seen. The kidneys of the diabetic non-calculogenic rats on low vitamin A diet at magnification x200 showed 3-5 crystals per field. Some of the crystals showed the typical shape of calcium monohydrate crystal. At magnification x900, large multifaceted crystals were seen. The significant number of polymorphic crystals and single large crystals seen in the kidneys of rats on high vitamin C diet indicates the tendency for crystal aggregation in these rats. The calcium oxalate monohydrate crystals and large multifaceted crystals seen in the kidneys of the diabetic non-calculogenic rats on low vitamin A diet indicate the propensity to promote crystal aggregation, which can lead to urolithiasis. The present study clearly point that diets high in vitamin C and low in vitamin A in can aggravate the calculogenic propensity in diabetic rats.

Keywords: Diabetic non-calculogenic, Diabetes mellitus, Calcium oxalate monohydrate, Calculogenic propensity, Crystal aggregation, Scanning Electron Microscope.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia