A CROSS-SECTIONAL STUDY OF ASSOCIATION OF INTRARENAL VASCULAR RESISTANCE WITH BIOCHEMICAL PARAMETERS IN PATIENT WITH TYPE-1 DIABETES MELLITUS

*Dr. Shyam Sunder Hembram, Dr. Saurav Das, Dr. Khokan Mandi and Dr. Ram Chandra Bhadra

ABSTRACT

Background: The present study aims at identifying early vascular changes which may help to identify children with early progression of diabetic nephropathy by using non-invasive doppler study and if clinically useful information is obtained it may be useful in follow up for the treatment. Materials and methods: This cross-sectional study was done in a tertiary care hospital in India. A total of 120 samples were taken in which 60 were patients with type 1 diabetes mellitus and 60 were age, sex and BMI matched healthy controls. The doppler parameters like renal Resistivity index, Peak systolic velocity and End diastolic velocity and various blood parameters were evaluated and compared between the cases and controls. Results: Peak systolic velocity of the cases was significantly higher than the controls (p=0.037). End diastolic velocity of cases was lower than the controls. Resistivity index of cases was significantly higher than the controls (p=0.001). Among the blood parameters, HbA1C, ACR, GFR, triglyceride, LDL and HDL were found to vary significantly between cases and controls (p<0.05). Conclusion: The doppler parameters like renal Resistivity index, Peak systolic velocity and End diastolic velocity can be used as potential tools to identify early progression of diabetic nephropathy in children.

Keywords: Diabetic nephropathy, Doppler, Resistivity index, Peak systolic velocity and End diastolic velocity.