DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS SECONDARY TO PHENYTOIN

Meenakshi Patial*

ABSTRACT

Drug rash with eosinophilia and systemic symptoms syndrome is a serious idiosyncratic drug reaction. It develops anywhere from 2 to 8 weeks after initiating the offending drug with variety of clinical manifestations, usually fever, rash, lymphadenopathy, eosinophilia, and visceral organ involvement, most commonly hepatitis. The mortality rate associated with DRESS syndrome is approximately 10%, the most common cause being fulminant liver failure.

Keywords: Eosinophilia, erythroderma.