SYNTHETIC HETEROCYCLIC CANDIDATES AS PROMISING ESTROGEN RECEPTOR ALPHA INHIBITORS; AN OVERVIEW

Shahma Mariyam*, Biju C. R., G. Babu, Adhiti Sibi and Rinjuna Reenas

ABSTRACT

There has been a lot of curiosity in estradiol's mode of action and potential therapeutic benefit ever since it was discovered and its chemical structure was elucidated. It is now widely accepted that estrogens serve a variety of purposes in numerous cell types. Controlling reproductive function, bone metabolism, cardiovascular diseases, as well as the prevention of mood swings, Alzheimer's disease, cancer, and hot flushes are all possible therapeutic uses for estrogens. For over a decade, it was thought that estrogens signal through a single estrogen receptor, now known as Estrogen receptor alpha (ER-α), which belongs to a family of ligand-activated transcription factors. Yet more recently, a second estrogen receptor called ER-β was discovered. In the present review we have covered the role of estrogen receptor α antagonists as anticancer agents.

Keywords: Estrogen receptor alpha, Anticancer, Indole, Pyrimidine.