SOLID DISPERSIONS: A TECHNIQUE OF SOLUBILITY ENHANCEMENT METHOD COMPREHENSIVE REVIEW

Pranitha Bhuthkuri*, Divya Bikkumalla, Apoorva Gourishetti, Hyma P.

ABSTRACT

During preparation of every pharmaceutical formulation the main goal is to deliver the product with good bioavailability, because it is the main parameter that contributes to the therapeutic activity of the drug molecule. The major drawback in most of the formulations existing today is solubility which directly effects dissolution, poor dissolution effects bioavailability at end. To address the solubility problem of a drug molecule, we have many solubility enhancement methods for poorly water-soluble drugs such as Micronization, nanoparticles, use of salt forms and use of surfactant spray freezing etc. Every method has its own limitations, like in micronization of the drugs often leads to agglomeration and decreases the wettability.so, solid dispersions methods like hot melt extrusion, solvent evaporation, spray drying, supercritical fluid methods etc. are the promising methods to address all the problems of solubility and bioavailability. This article gives an overall view of solid dispersions and its role in improving solubility and bioavailability of poorly water-soluble drugs.

Keywords: Solid dispersion, Bioavailability, supercritical fluid extraction, solvent evaporation, cellulose polymers, stability, solubility.