( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Pappu Harish, Polavarpu Sowjanya, Dr. Achukatla Kumar and Dr. G. P. V. Sangeetha


Obesity is a growing problem worldwide, with over 650 million obese adults, and has tripled since 1975. It's caused by excessive body fat due to eating too many calories, a sedentary lifestyle, and genetic susceptibility, leading to health issues such as high cholesterol, blood pressure, and risk of secondary diseases. Type 2 diabetes is a complex illness caused by genetic, environmental, and behavioral risk factors, leading to insulin resistance and hyperglycemia. β cells in the islets of Langerhans secrete insulin, which regulates the metabolism of carbohydrates, proteins, and fats by facilitating the uptake of molecules such as glucose from the bloodstream into the liver, fat, and skeletal muscle cells. High glucose stimulates metabolic pathways, generating oxidative stress and insulin resistance, disruptions in insulin signaling due to excess fatty acids and cytokines. Insulin resistance impairs the body's response to insulin, causing hyperinsulinemia and metabolic problems, including type 2 diabetes. Metabolic syndrome and insulin resistance syndrome are clinical indicators of insulin resistance, with specific criteria for diagnosis. It is believed that inflammation plays an important role in regulating metabolism and energy balance, which may lead to new treatments and diagnostic equipment for the treatment of obesity-related insulin resistance. Obesity and insulin resistance research have a promising future, with many exciting developments on the horizon. This may entail utilizing multi-omics methods, such as genomics, transcriptomics, proteomics, and metabolomics, to obtain a more comprehensive understanding of the cellular mechanisms implicated in insulin resistance. In this review, we will discuss the relationship between obesity and the risk of developing insulin resistance, as well as the possible mechanisms underlying this process.

Keywords: Obesity, insulin-dependent diabetes mellitus, Insulin resistance, inflammation, hyperinsulinemia, oxidative stress, Metabolic syndrome.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2023 Issue has been Published, Kindly check it on


    SEPTEMBER issue has been successfully launched on 1 SEPTEMBER 2023.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

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  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database