FORMULATION AND EVALUATION OF AN IN SITU GEL-FORMING OPHTHALMIC FORMULATION OF FLUROQUINOLONE DRUG

Geethu J.*, Dr. Rakesh Kumar Jaat and Dr. J. Jaslin Edward

ABSTRACT

Most commonly available ophthalmic preparations are eye drops and ointments. The eye as a portal for drug delivery is generally used for local therapy to avoid the risk of eye damage. In eye the target tissue absorbs a very less fraction of drug. Due to this reason, concentrated solutions and frequent dosing are required for the instillation to achieve an adequate level of therapeutic effect. The in situ gel forming ophthalmic formulations are directly inserted in to the cul-de-sac that space is between the sclera and eyelid. Compared with the conventional dosage forms these gel provide comfort to the patient. The objective of planning a supportive system is to give and accomplish the right centralization of a drug at the fitting term and dynamic area.

Keywords: cul-de-sac, in situ gel.