EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF RHIZOME OF DRYOPTERIS COCHLEATA

Sattwik Das* and Shailendra Lariya

ABSTRACT

Objective: To evaluate the antidiabetic effects of ethanolic extracts of Dryopteris cochleata rhizome (EDC) in Wister rats. Methods: Alloxan induced diabetic test model were performed to evaluate antidiabetic activity of EDC at two different doses 100 and 200 mg/kg respectively. Ethanolic extract of rhizome of Dryopteris Cochleata (Dryopteridaceae) was tested for anti-diabetic activity for alloxan induced diabetics in wistar rats. After oral administration of the extract at two different doses (100 and 200mg/kg body weight) for 15 days to alloxan-induced diabetic rats, the blood glucose, level was assayed periodically on 0, 7th and 15th day. After 15 days treatment all biochemical parameters like total cholesterol, triglyceride, total protein levels were checked and compare with control and standard group and body weight was also determine which was compare with initial weight. Results: Ethanolic extract shown significant protection and lowered induced blood glucose level to normal in glucose tolerance test on the day 0,7th and 15th compare with diabetic control and standard groups. There was significant control of all biochemical parameters levels like total cholesterol, triglyceride, total protein in extracts of Dryopteris cochleata treated diabetic rats. Marked body weight loss was observed in diabetic rats. The data obtained from this study showed that the treatment of extracts Dryopteris cochleata protect the diabetic rats from loss of massive body. Conclusions: These results indicate that the rhizome of Dryopteris cochleata posses significant anti-diabetic activity.

Keywords: Antidiabetic activity, Dryopteris cochleata, Dryopteridaceae, Alloxan- induced diabetis, biochemical parameters.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )