ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF RHIZOME OF DRYOPTERIS COCHLEATA

Sattwik Das* and Shailendra Lariya

ABSTRACT

Objective: To evaluate the antidiabetic effects of ethanolic extracts of Dryopteris cochleata rhizome (EDC) in Wister rats. Methods: Alloxan induced diabetic test model were performed to evaluate antidiabetic activity of EDC at two different doses 100 and 200 mg/kg respectively. Ethanolic extract of rhizome of Dryopteris Cochleata (Dryopteridaceae) was tested for anti-diabetic activity for alloxan induced diabetics in wistar rats. After oral administration of the extract at two different doses (100 and 200mg/kg body weight) for 15 days to alloxan-induced diabetic rats, the blood glucose, level was assayed periodically on 0, 7th and 15th day. After 15 days treatment all biochemical parameters like total cholesterol, triglyceride, total protein levels were checked and compare with control and standard group and body weight was also determine which was compare with initial weight. Results: Ethanolic extract shown significant protection and lowered induced blood glucose level to normal in glucose tolerance test on the day 0,7th and 15th compare with diabetic control and standard groups. There was significant control of all biochemical parameters levels like total cholesterol, triglyceride, total protein in extracts of Dryopteris cochleata treated diabetic rats. Marked body weight loss was observed in diabetic rats. The data obtained from this study showed that the treatment of extracts Dryopteris cochleata protect the diabetic rats from loss of massive body. Conclusions: These results indicate that the rhizome of Dryopteris cochleata posses significant anti-diabetic activity.

Keywords: Antidiabetic activity, Dryopteris cochleata, Dryopteridaceae, Alloxan- induced diabetis, biochemical parameters.