FORMULATION DEVELOPMENT, CHARACTERIZATION AND INVITRO EVALUATION OF ANTI DIABETIC DRUG FLOATING DRUG DELIVERY SYSTEM

Shaik Karishma, V. Jhansi Priya Marabathuni* and Naidu Narapusetty

ABSTRACT

In the present work, the cellulose polymers EC was used to develop floating drug delivery systems which will modify the release of rosiglitazone. Owing to prolonged residence time at absorption site, enhanced bioavailability can be attained. Optimized formulations show satisfactory drug release upto 12 hours. The observed release mechanism from microspheres was diffusion and erosion controlled. The optimized formulation during stability studies does not show any variation in physicochemical properties of microspheres. Thus, successful development of controlled release floating microspheres of RG was achieved during the research work, which signifies the possibility to increase the systemic effect of drug via gastroretentive system on the basis of floatation.

Keywords: Floating drug delivery system, cellulose polymers, stability, bioavailability.