SPANLASTICS: A MODERN FORMULATION APPROACH IN DRUG DELIVERY
Vindhya V. S.*, Krishnananda Kamath K., Sandeep Kumar Jain and Shabaraya A. R.
In the field of nanotechnology, novel vesicular drug delivery systems have advanced significantly. These systems are valuable in evading various drawbacks associated with conventional dosage forms, like low aqueous solubility, poor bioavailability, poor membrane permeability, variable plasma concentration, undesirable effects, poor patient compliance, and poor patient efficacy. Thus, with the advent of novel drug delivery systems such as liposomes, nanoemulsions, nanosuspensions, and nanoparticles, these are proving to be a better option nowadays. A new system called Spanlastics, which has fewer side effects, was released in 2011 as part of the progression of drug delivery. They are a novel elastic vesicular drug delivery system based on surfactants that trap the drug in the core cavity in the form of a bilayer. Which are amphiphilic in nature, the drug is contained within a vesicle comprised of a non-ionic surfactant. They have been found to be more stable chemically. They provide medicinal ingredients with targeted delivery and regulated release, and they have overcome a number of problems with the traditional dosage form. The classification of spanlastics, the mechanism of penetration, various preparation techniques, evaluation factors, and applications are highlighted in the current review.
Keywords: Nanotechnology, Membrane permeability, Spanlastics, Surfactants.
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