A REVIEW OF ORALLY FAST DISSOLVING FILM OF D2 RECEPTOR ANTAGONIST

Makwana Rajeshree*, Vaghela Darshna, Chauhan Payal, Patel Dipali, Kiran Dobhal

ABSTRACT

The objective of the resent work was to formulate fast dissolving film of D2 receptor antagonist so as to achieve higher oral bioavailability by minimizing the first pass metabolism and to enhance the compliance by elderly and pediatric patients. D2 receptor antagonist being water insoluble drug pose a challenge in formulating fast dissolving film. So, in order to enhance the solubility solid dispersion were prepared using β-Cyclodextrin as carrier. The physical mixture and solid dispersion by kneading in the molar ratio 1:1, 1:2 and 1:3 of D2 receptor antagonist and β-Cyclodextrin were prepare and evaluated for drug content, %yield and in vitro drug release.For preparing film, initially trial batches were prepared utilizing HPMC E3, E5 and E15 LV and pulllulan as film forming polymers and PEG 400 as plasticizer. Based on the trial batchesthe best film forming agent was selected. Optimization of films were done by factorial design taking concentration of polymer and PEG 400 as dependent variable and tensile strength, %elongation, elastic modulus, disintegration time and drug release at 2 min were taken as dependent variables. Polynominal equation were derived and validity of equation was checked by preparing and evaluating chek point batches. Surface plots were constructed and desdirability of the film was calculated and based on it optimized batch for both plain drug and solid dispersion film was determined. Mechanical properties and drug release was compared between the two films and based on it the best film was finally selected.

Keywords: Fast dissolving film, ?-Cyclodextrin, Solid dispersion, Factorial design.