( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Makwana Rajeshree*, Vaghela Darshna, Chauhan Payal, Patel Dipali, Kiran Dobhal


The objective of the resent work was to formulate fast dissolving film of D2 receptor antagonist so as to achieve higher oral bioavailability by minimizing the first pass metabolism and to enhance the compliance by elderly and pediatric patients. D2 receptor antagonist being water insoluble drug pose a challenge in formulating fast dissolving film. So, in order to enhance the solubility solid dispersion were prepared using β-Cyclodextrin as carrier. The physical mixture and solid dispersion by kneading in the molar ratio 1:1, 1:2 and 1:3 of D2 receptor antagonist and β-Cyclodextrin were prepare and evaluated for drug content, %yield and in vitro drug release.For preparing film, initially trial batches were prepared utilizing HPMC E3, E5 and E15 LV and pulllulan as film forming polymers and PEG 400 as plasticizer. Based on the trial batchesthe best film forming agent was selected. Optimization of films were done by factorial design taking concentration of polymer and PEG 400 as dependent variable and tensile strength, %elongation, elastic modulus, disintegration time and drug release at 2 min were taken as dependent variables. Polynominal equation were derived and validity of equation was checked by preparing and evaluating chek point batches. Surface plots were constructed and desdirability of the film was calculated and based on it optimized batch for both plain drug and solid dispersion film was determined. Mechanical properties and drug release was compared between the two films and based on it the best film was finally selected.

Keywords: Fast dissolving film, ?-Cyclodextrin, Solid dispersion, Factorial design.

[Full Text Article]



  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database