INVESTIGATION OF NEUROPROTECTIVE EFFECT OF RASAGILINE IN DIABETIC NEUROPATHY IN STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC RATS
Amit Kumar Gangwar*
Background One of the most common complications of diabetes is the involvement of the peripheral and autonomic nervous systems . An important risk factor for the development of diabetic neuropathy in patients with type 1 or type 2 diabetes is the duration and severity of hyperglycaemia. Diabetic neuropathy is ―the presence of symptoms and/or signs of peripheral nerve dysfunction in persons with diabetes after the exclusion of other causes.‖ Till date there is no effective treatment available for diabetic neuropathy, However, it can be managed using certain pharmacological and, non-pharmacological treatments. The aim of this study is to investigate the neuroprotective effect of rasagiline in diabetic neuropathy. Methods: Diabetes was induced by a single dose of STZ (60 mg/kg i.p). After the administration of Streptozotocin the animals showed marked hyperglycaemia, reduction in body weight and other signs of neuropathy like thermal allodynia (hot and cold), thermal hyperalgesia and motor co-ordination was compared to the animals of the control group. Results : After 28 days of treatment with Rasagiline ( 0.25 mg/kg, 0.5 mg/kg, 1.0 mg/kg) in combination with Glimepiride ( 10 mg/kg), rats showed significant reduction in serum glucose level, and improvement in body weight. Rasagiline combined with Glimepiride showed good results in different parameters such as thermal allodynia (hot and cold), thermal hyperalgesia and motor co-ordination in comparison with diabetic control group. The most significant effect was seen with 1.0 mg/kg of rasagiline in combination with Glimepiride (10 mg/kg) after 28th day of treatment. Conclusion: Rasagiline can, therefore, be concluded to be effective treatment option for diabetic complications like neuropathy. This is due to its inhibitory effect on MAO-B.
Keywords: thermal hyperalgesia, thermal allodynia, cold allodynia and motor inco-ordination.
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