EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

OMEGA-3 FATTY ACIDS SUPPLEMENTATION IN HEALTHY INDIVIDUALS

Mo Mo Than*, Zaw Min Htut, Yan Naing Soe, Kyaw Khine, Kyaw Myo Htun and Ko Ko Lwin

ABSTRACT

Introduction: Omega-3 fatty acids are dietary fats with a variety of health benefits. A growing body of research on omega-3 supplementation has shown that these fatty acids influence neurotrophins related to cognitive function; decreasing lipid peroxidation; attenuating activities on inflammatory eicosanoids, presumably have antioxidant effects, anti-inflammatory benefits, and immunomodulatory effects; can prevent atherosclerosis in both human and animal models. Aim: This study aimed to evaluate the effect of omega-3 fatty acids supplementation on serum BDNF & cognitive function, Oxidative Stress Index (OSI), serum inflammatory markers as well as lipid profile of healthy adults. Methods: A total of 35 young, healthy adults participated in this pre- and post-interventional study. Each participant received one fish oil supplement comprising 1000 mg twice daily for 12 weeks. Before and after the intervention, their fasting blood samples were analyzed for serum levels of BDNF, total oxidative stress (TOS), total antioxidant stress (TAS), TNF-α, IL-6, lipid profile, and cholesterol ester transfer protein (CETP) by ELISA method. Calculation of OSI and cognitive function tests (revised Hasegawa's dementia scale; HDS-R) were also done. Results: After 12 weeks of supplementation, mean serum BDNF and CETP levels were significantly increased, with a substantial decrease in mean serum levels of TNF-α, IL-6, TG, and VLDL as well as OSI. Mean HDS-R was likely to increase after supplementation although it was not statistically significant. Conclusion: Therefore, daily omega-3 fatty acids supplementation for 12 weeks has shown beneficial outcomes on health with positive neurocognitive function, anti-oxidant improvement, anti-inflammatory action, and lipid-lowering effects even in healthy individuals.

Keywords: Omega-3 fatty acids, BDNF, HDS-R, Inflammatory markers, OSI, Lipid profiles.

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