EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

IN VITRO ANTACID EFFECTS OF KHAYA GRANDIFOLIOLA (MELIACEAE) AND CURATIVE EFFECTS FORMULATED WITH CLAY (MY41G) ON CHRONIC GASTRIC ULCERS IN RATS

Essama M. D. Sandrine*, Ndji Otto Gustave Lebeau, Emakoua Joseph Fleurie and Tan Paul Vernyuy

ABSTRACT

Aim: The current study investigated the in vitro antiacide and in vivo curative actions of aqueous extract of Khaya grandifoliola + MY41gc clay in rats. Materials and Methods: This study evaluated possible antacid action with the neutralizing effect (in vitro) of the extract against pylorus ligation; and curative effects of Khaya grandifoliola combined with MY41gc clay on chronic gastric ulcers in rats. Chronic gastric ulcers were induced by injecting 0.05 mL of acetic acid (30 %) into the stomach wall. From day 5-10 after induction of ulcers, rats were treated daily with the mixture of K. grandifoliola + MY41gc clay (250 + 250 and 250 + 500) mg/kg. The ulcer index, percentage of healing, mucus secretion, histological parameters, and oxidative stress parameters were assessed. In vitro, K. grandifoliola had antacid and neutralizing effects practically similar of sodium bicarbonate. Curative treatment with K. grandifoliola + MY41gc clay solution for 10 days resulted in accelerated spontaneous healing of chronic gastric ulcers in both formulation (66.26-100 %) and promoted significantly higher levels of catalase and highly decreased levels of MDA in rats. Conclusion: K. grandifoliola possess neutralizing effects and his formulation with MY41gc clay has curative actions in rats.

Keywords: Neutralizing effect, chronic gastric ulcers, MY41gc clay.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia