A REVIEW ON TARGETED DRUG DELIVERY SYSTEM

Sri Ranga T., Siddalinga Swamy PM*, Chandana CM, Suchitra TS, Thanmayi MO, Anjali KK and Vijayalakshmi MA

ABSTRACT

New form of drug delivery system is drug targeting. The goal of the drug targeting is to deliver the drug to that targeted site of action without releasing the drug at non targeted site or without damaging other tissues/organs/cells. It has more advantages over conventional drug delivery system like low side effects, improvement of pharmaceutical activity and reduction of administered dose. The main reason of the targeted drug delivery system is to provide good pharmacological therapeutic agents for diseased organs without harming healthy tissues. Cancer treatment with chemotherapeutic agents have more side , targeted drug delivery system serve a purpose to reduce those side effects. various drug carrier which can be used in this advance delivery system are soluble polymers, biodegradable, microsphere polymers (synthetic and natural), neutrophils, nanoparticles, lipoproteins, liposomes, micells, niosomes, these carriers maintain and transport the loaded drug to the pre-selected organ. Drug targeting have a different mechanisms such as passive targeting, inverse targeting, active targeting, physical targeting, ligand-mediated targeting, dual targeting and double targeting. Targeted drug delivery system is useful for delivering the therapeutic agent to a particular site of action without causing any virulent effect to other organs.[2] GOAL OF TDDS To prolong, localize target and have a protected drug interaction with a diseased tissue.[³]

Keywords: Therapeutically active drug, drug delivery, drug targeting, chemotherapeutic agents, therapeutic action.