FORMULATION DEVELOPMENT AND EVALUATION OF ERLOTINIB NASOSPONGES
Nunna Tejo Manikanta Naidu, V. Jhansi Priya Marabathuni* and Naidu Narapusetty
Nanosponges of Erlotinib was prepared by the solvent evaporation technique by employing Ethyl Cellulose, β Cyclodextrin and poloxamer as rate retarding polymers using PVA as a copolymer. However, at higher ratios, drug crystals were observed on the nanosponge surface. Increase in the drug/polymer ratio (1:3 to 1:1) which is in increasing order due to the increase in the concentration of polymer. However, after a particular concentration, it was observed that as the ratio of Drug to polymer was increased, the particle size decreased. The particle size was found in the range of 250- 450 nm. The entrapment efficiency of different formulations were found in the range of 90.56 to 98.32%, By comparing the above dissolution studies of formulations F1-F9. Maximum drug release was found in F5 formulation containing Drug: β-cyclodextrin in 1:3 ratio. So F5 formulation was taken as the optimized formulation, and drug release kinetics were performed and which follows zero-order kinetics with super case II transport mechanism.
Keywords: Erlotinib, ?-Cyclodextrin, Poloxamer, Ethyl Cellulose, Nanosponges Delivery.
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