( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Dr. Bhupesh Dewan*, Dr. Vikram Gharge, Siddheshwar Shinde and Janaki Chaudhary


Background: Lactic acid bacillus spores (Bacillus coagulans) has excellent stability and shows therapeutic effects on intestinal diseases, such as acute diarrhoea, irritable bowel syndrome, antibiotic-related diarrhoea, constipation and colitis. Spores of Lactic acid bacillus resist gastric acid to reach the small intestine, where they can germinate and propagate. There is an existing misconception that antibiotics degrade the probiotics when given in conjunction. Aim: To study the survival, germination and proliferation of Lactic acid bacillus spores in presence of Amoxicillin/Clavulanate antibiotic. Method: ‘Augpen LB®-625’ tablet (FDC tablet of Amoxicillin 500 mg, Potassium Clavulanate 125 mg with Lactic acid bacillus 60 million spores) is dissolved in 0.1N HCl and pH 6.8 phosphate buffer. It was diluted and incubated in MRS broth and mixed with PNY agar media, followed by solidification and repeated incubation. The resulted number of colonies in each plate was counted. Results: It was observed that 60 million spores of lactic acid bacillus present in the ‘Augpen LB®-625’ tablet produced 7.3 billion CFU at 24 hours and 51 billion CFU at 72 hours under suitable conditions mimicking human intestinal pH, which helps in intestinal colonization with the probiotics. Conclusion: This study provides the evidence for survivability of the probiotic Lactic acid bacillus in acidic pH and its germination in presence of Amoxicillin and Clavulanate.

Keywords: Germination, Lactic acid bacillus, Spores, Probiotic, Amoxicillin/Clavulanate.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia