EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

OXIDATIVE STRESS AND ANTIOXIDANTS AMONG WOMEN WITH PREECLAMPSIA AT A TERTIARY HEALTH FACILITY IN NORTH-WESTERN NIGERIA

Olatunji G.O.*, Adamu N.A., Lawal I., Shehu A., Ibrahim U.A.

ABSTRACT

Background: Preeclampsia is a potentially dangerous complication of pregnancy. The cause remains largely unknown. Oxidative stress, which is a negative balance between oxidants and antioxidants, has been implicated in its pathogenesis. Free radicals released by the ischemic placenta is thought to be responsible for the impaired endothelial cell function. We evaluated the oxidative stress marker (oxidant), malondialdehyde (MDA) and antioxidants (Superoxide dismutase and Zinc) in preeclamptic women, and their correlation with severity of preeclampsia. Materials and Methods: It was a cross-sectional study of women diagnosed with preeclampsia matched with normotensive pregnant women. Serum MDA, Superoxide dismutase (SOD) and Zinc of the participants were measured. Severity of preeclampsia was assessed by the blood pressure at presentation. Statistical analysis was done using SPSS version 24. Results: There was no difference in the level of MDA between women with preeclampsia and normotensive pregnant women (p = 0.505). SOD was significantly higher (p < 0.001), with a positive correlation with severity of preeclampsia (Systolic blood pressure (ρ = 0.289, p < 0.001) diastolic blood pressure ρ = 0.258, p < 0.001), while zinc was significantly lower (p < 0.001), with a negative correlation with severity of preeclampsia (systolic blood pressure ρ = - 0.212, p = 0.004), diastolic blood pressure ρ = -0.203, p = 0.006). Conclusion: In this study, there was a difference in the level of the antioxidants between women with preeclampsia and normotensive pregnant women, which correlated with the severity of preeclampsia.

Keywords: Oxidative stress; Preeclampsia; Malondialdehyde; Antioxidants.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia