EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SYNTHESIS AND EVALUATION OF BENZOTHIAZOLE DERIVATIVES FOR ANTHELMINTIC ACTIVITY

Gaware Vinayak M.*, Dhamak Kiran B. and Kotade Kiran B.

ABSTRACT

Derivatives of benzothiazoles were synthesized and evaluated for their anthelmintic activity. 2-amino benzothiazole was first converted to 6 substituted derivatives of 2-amino benzothiazole by nitration and bromination reaction to yield 6-nitro-2-amino benzothiazole and 6-bromo-2-amino benzothiazole respectively. All the derivatives including 2-amino benzothiazole were further treated with chloroacetyl chloride to form chloroacetamido derivatives of benzothiazole. Further the product is treated with various heterocyclic and aromatic amines. The synthesized compounds were confirmed by IR, 1H NMR and Mass spectral data. Synthesized substituted benzothiazole derivatives were investigated for their anthelmintic activity against Indian adult earthworms (pheretima posthuma) at various concentrations (25 mg/ml and 50 mg/ml) .It was observed that the new synthesized compounds possessing electron withdrawing group like nitro and bromo groups at 6th position of benzothiazole nucleus and chloro, fluoro substituted at 3rd position of aromatic amine exhibited higher anthelmintic activity when compared to that of other synthesized compounds. The present research focus on the different methods of synthesis of substituted benzothiazoles with potential anthelmintic activity that are now in developing phase.

Keywords: Anthelmintic, Albendazole, Benzothiazole; Bromination; Nitration.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia