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 ISSN 2394-3211

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Dr. Nandini M. S., Raghu J. D.* and Narendra R.


Background and Objectives: Acmella oppositifolia is an Indian medicinal plant belongs to the family Asteraceae. The present study has been designed to screen the anthelmintic activity of ethanolic extract of Acmella oppositifolia. Methodology: To evaluate the in vitro anthelmintic activity of ethanolic extract of Acmella oppositifolia we have selected the adult Indian earthworms, Pheretima posthuma. In this study dried extract was taken in 1% w/v carboxymethyl cellulose and prepared in normal saline in three different concentrations (25, 50, 100 mg/ml). The suspension of Albendazole taken in same three concentration considered as standard and normal saline water with 1% CMC was taken as a control. All the worms were placed in petri dish containing 15 ml of sample (drug) solution. Time taken for paralysis (Vermifuge) was noted either when any movement could not be observed except when the worms were shaken vigorously or when dipped in warm water (50 0C). Death (Vermicidal) was included when the worms lost their motility followed by white secretions and fading away of their body colour. Results: Ethanolic extract of Acmella oppositifolia has exhibited significant anthelmintic activity at all the tested concentrations when compared to standard drug since vermifuge and vermicidal effect was highly significant at the higher concentration (100 mg/ml). Conclusion: The current investigation leads to conclusion that the Acmella oppositifolia have potent anthelmintic activity when compare with the standard albendazole drug. Therefore, we can use this plant as an alternative source of anthelmintic drug and the activities may probably due to the presence of flavonoids, glycosides, saponins, alkaloids and triterpenes.

Keywords: Acmella oppositifolia, Anthelmintic activity, Albendazole, Vermifuge, Vermicidal.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia