COMPARISON OF SERUM ESTRADIOL LEVEL BETWEEN SURGICAL AND NATURAL MENOPAUSE

Mehnaz Rashida Hossain*, Nigar Sultana, Jenifa Haque Zuthy, Rawshon Jahan Bithi

ABSTRACT

Surgical menopausal women suffer from sudden hormonal imbalance due to decrease in ovarian function even after simple hysterectomy without any oophorectomy. Many postmenopausal symptoms were observed in women with surgical menopause. The aim of this study was to compare the serum estradiol level between surgical and natural menopause. This cross-sectional comparative study was conducted in outpatient Department of Obstetrics and Gynaecology, Institute of Child and Mother Health (ICMH), Matuail, Dhaka from March 2019 to June 2020. A total of 60 subjects were selected based on exclusion and inclusion criteria, where group A consisted of 30 surgical menopausal women and group B consisted of 30 natural menopausal women. Data was collected in pre-fixed questionnaire form by the researcher herself. Mean serum estradiol was found 10.6±3.0 pg/ml in group A and 20.3±8.0 pg/ml in group B. The difference was statistically significant (p=0.001) between two groups. Normal serum estradiol level in menopause is 10-25 pg/ml with an average of 15 pg/ml. In group A, 19 (63.3%) and 11 (36.7%) study subjects had serum estradiol level of ≤10.0 pg/ml and 10.1-20 pg/ml, and in group B, 1(3.3%), 19 (63.3%), 6(20%) and 4 (13.3%) had serum estradiol level of ≤10.0 pg/ml, 10.1-20 pg/ml, 20.1-30 pg/ml and >30 pg/ml respectively. After analyzing the results, it can be concluded serum estradiol level was significantly decreased in surgical menopause than natural menopause.

Keywords: Surgical menopause, natural menopause, serum estradiol.