FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILM OF AN ANTI-DIABETIC DRUG GLIPIZIDE

Menakshi, Mahesh Bhatt* and Chitra*

ABSTRACT

The present study was to formulated and evaluated oral fast dissolving film of glipizide for the treatment of diabetes mellitus. Glipizide comes as tablets and extended-release(long acting) tablets to take by mouth.Glipizide is used along with diet and exercise,some times with other medication, to treat type 2 diabetes (condition in which body does not use insulin normally and, therefore, can not control the amount of sugar in the blood). Glipizide is in a class of medications called sulfonylureas. Film are thin and semisolid in nature. The film form can be swallowed easily with the connected of saliva fluid and they are disintegrate rapidly and quick absorbed by buccal mucosa. Medicated film of glipizide was formulated using polymer like, HPMC, carbocol. The prepared medicated film were evaluated for their physic- chemical properties like surface pH, thickness, folding endurance, drug release and drug content. G2 formulation was the best obtained formulation.

Keywords: Glipizide, Material and methods, Discussion, Conclusion.