EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION VARIABLES AND PROCESS VARIABLES IN COLON TARGETED CAPSULE DOSAGE FORM

Lata Panchal and Prakruti Amin*

ABSTRACT

Recent studies show its ability to target certain drugs and/or peptides to the colonic region for the treatment of several diseases while avoiding systemic absorption and potential side effects, colon drug delivery has become a field of research of growing interest. Anything which is taken orally will start to dissolve very quickly. Capsule is one of them which includes medication enclosed in a shell. When this shell breaks down in the digestive tract and the medication is absorbed into the bloodstream then drug is distributed and metabolized in similar pattern to the tablet. In the stomach, pH ranges between 1 and 2 during fasting but increases after eating. The polymers described as pH dependent in colon specific drug delivery are insoluble at low pH levels but become increasingly soluble as pH rises. Many drugs are unstable at the acidic pH of stomach therefore many of the tablets and capsules carries a special gastro-resistant coating. Various factors that can affect this targeting and drug release are reviewed in this article. Formulation variables and process variables are critical parameters need to be controlled for optimized drug delivery to the colon. Formulation ingredients play a key role in releasing drug in a controlled manner or to the target site. Local or systemic effect and immediate or prolonger drug release can be possible by varying the type and amount of polymers used in the formulation and also by various approaches such as pH-dependent systems, enzyme-activated systems, receptor-based systems, magnetically activated systems and combination approaches such as Phloral™ technology are also responsible for release of the drug to the target site like colon. This review focuses on Formulation variables and process variables in colon targeted capsule dosage form.

Keywords: Formulation variable, Process variable, Colon targeted, Capsule, Enteric coating, Phloral, Encap, Encode.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia