EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARISON OF PROPOFOL-REMIFENTANYL AND PROPOFOL-DEXMEDETOMIDINE USE IN OUTPATIENT ENDOMETRIAL BIOPSIES AND/OR CURETTAGES

Aslan Bilge (M.D)*, Güner Beyhan (M.D), Aktürk Hilal (M.D), Abdullah Atar (Assistant Technician)

ABSTRACT

Introduction: Using single anesthetic agent in endometrial biopsy sampling and/or probe curettage (EBS and/or PC) may lead to inadequate analgesia and sedation. To achieve the adequate analgesia and sedation the single anesthetic agent doses must be increased which causes unwanted side effects. For avoiding high doses of single anesthetic agent nowadays combination with sedative agents is mostly a choice for analgesia and sedation for EBS and/or PC. Aim: The aim of this study is to investigate the effects of propofol + remifentanil, and propofol + dexmedetomidine combinations on the total dose of propofol to be administered during EBS and/or PC and on the pain scores after the process. Materials and Method. This randomized study was performed with 108 patients (ASA I-II-III) ranging between 18 and 70 years of age who underwent sedation/analgesia for elective . The patients were administered remifentanil (1 μg/kg) + propofol (1,5 mg/kg) in Group Ι, dexmedetomidine (1 μg/kg) + propofol (1,5 mg/kg) combination in Group II. All the patients‟ sedation levels were assessed with the Ramsey Sedation Scale (RSS). Their recovery was assessed with the Aldrete and Numerical Rating Scale Score (NRS) at 10 min intervals. Results. The total doses of propofol administered to the patients in the two groups in this study were as follows: 150 mg in Group I, and 245 mg in Group II. Conclusion: Propofol-dexmedetomidine combination is as effective as propofol-remifentanil combination but with fewer side effects for conscious sedation during EBS and/or PC sugery. It was observed that, in the patients undergoing EBS and/or PC, administration of propofol in combination with an opioid or α2 receptor agonist provided effective and reliable sedation, reduced the total dose of propofol, increased the practitioner satisfaction, decreased the pain level, and provided hemodynamic stability . Sedation Score, patients‟ satisfaction, surgeons‟ satisfaction, heart rate, mean arterial blood pressure, and oxygen saturation were recorded. Side effects such as respiratory depression, nausea, vomiting, airway obstruction, and oxygen desaturation were also recorded.

Keywords: Probe curtaj - Conscious sedation - Narcotics - Adrenergic alpha2 receptor agonists.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia