EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

PERINATAL OUTCOMES AMONG WOMEN WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY IN A SECONDARY CARE CENTRE: A PROSPECTIVE STUDY

Dr. Twinkle Sood and *Dr. Divya Dhiman

ABSTRACT

Background: Intrahepatic cholestasis of pregnancy (ICP), also described as obstetric cholestasis is the second most common cause of icterus in pregnancy. Although not fully understood, proposed theories indicate it could be due to decreased bile flow through the liver and its poor excretion, leading to increased levels of colic and chenodeoxycholic acid. It is known to be associated with adverse maternal and fetal outcomes. Methods: This was a prospective observational study carried out in a secondary care hospital. Total 800 pregnant women were screened during the study period. Patients with ICP were identified in out-patient department (OPD) of obstetrics and gynaecology after eliciting history about itching. Pregnancies with pregnancy induced hypertension and other liver diseases in pregnancy were excluded. Results: 64 pregnant women with prevalence rate of 8% were found to be suffering from ICP. Majority of the population suffering from ICP were multiparous women (65.6%) in the age group of 26-30 years (54.7%). Most common foetal complications encountered were meconium staining of liquor (46.9%) and low birth weight (45.3%). Other adverse foetal outcomes were preterm delivery, abnormal CTG and increased risk of NICU admissions. Maternal complications included increased chances of lower segment caesarean section (LSCS) (57.8%), insomnia (59.4%), PPROM (17.2%) and PPH (18.8%). Conclusions: Proper history taking should be undertaken to screen women with ICP in the antenatal period. The delivery team should be prepared to manage meconium aspiration in the newborn.

Keywords: Intrahepatic cholestasis of pregnancy, perinatal complications, secondary care.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia