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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Henry Diassy, Charlot Diatta, Firmin Sylva Barboza, Fatimata Seydy Ball, Marie Sow, El Hadji Dione, Abdoulaye Gassama and Guata Yoro Sy*


Previous work had demonstrated the lack of hypoglycemic effect of the butanol-ethyl acetate fraction (BEAF) of the leaves of Dialium Guineense (Caesalpiniaceae). However, this same fraction is anti-hyperglycemic in glucose tolerance test in type 2 diabetic rats. The purpose of that study was to evaluate the effect on blood glucose of dietyl terephthalate (DT) isolated from BEAF of D. guineense leaves. Diethyl terephthalate (DT) was tested in normoglycemic rats, glucose tolerance test and type 2 diabetic rats. Per os administration of DT in normoglycemic rats is not associated with a significant change in basic blood glucose. At 30 mg/kg per os, blood glucose ranges from 0.76±0.02 to 0.84±0.02 g/L (ns, n=5). Under the same conditions, similar results were observed at 100 mg/kg per os (0.91±0.04 vs 0.95±0.03 g/L) (ns, n=5). In glucose tolerance test, prior administration of DT (30 mg/kg, 100 mg/kg, per os) significantly prevents the appearance of frank hyperglycemia. The blood glucose was 1.10±0.04 g/L and 1.29±0.08 g/L, respectively at 30 mg/kg and 100 mg/kg per os, after DT administration vs 2.04±0.13 g/L in control group (p<0.05, n=5). The daily administration of DT (30 mg/kg, per os) in type 2 diabetic rats significantly prevents the hyperglycemia previously observed in the control group. The effect profile on blood glucose of DT is identical to that butanol-ethyl acetate fraction (BEAF) of the leaves of D. guineense and is reminiscent that of antihyperglycemic agents of thiazolidine-dione group. The anti-hyperglycemic action of DT would involve the body peripheral tissues.

Keywords: Dialium guineense, Leaves, Blood glucose, Diethyl terephthalate.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia