SALIVAOMICS– A GATE WAY TO BI DIRECTIONAL (ORO-SYSTEMIC) EXPLORATION

Dr. Bushra Ijaz*, Dr. Farzeen Tanwir, Dr. Tauqeer Bibi, Dr. Saima Mazhar, Dr. Fatima Khaleeq and Dr. Rida Zulfiqar

ABSTRACT

Saliva has been a common fluid specimen that is important for diagnostic purpose for decades now. It can be used as a resourceful tool in the field of medicine, forensics, immune system endocrinology, psychology, dentistry, and related diseases. Lately, its use as an investigative tool has become a new normal. Saliva can be used to detect bone metabolic disorder. It performs several function like lubrication, cleaning of oral cavity also aid in deglutition and mastication process. The human saliva metabolome is a development in point-of-care diagnostic technology. In addition, Salivaomics is the study of saliva and its functions, constituents, and related techniques. Biomarkers such as growth factors, bio molecule, enzymes, and interleukins are useful in evaluating, risk, and prognosis and follow-up of disease. Saliva can be used to detect bone metabolic disorder. Along with its role in oral cavity, saliva in analyzing the levels of medicines and drugs in blood has achieved much significance. It can be used in the detection of different drugs as well as can be used as marker for viral, acute and congenital infections. The diversity of constituents in this fluid can serve as biomarkers for examining the presence or absence various systemic and local diseases. This article is about diagnostic perspective of salivary metabolome.

Keywords: Biomarkers, Biofluid, Diagnostics, Salivary metabolome, Salivaomics, Saliva.