MULTICOMPONENT SYNTHESIS OF PYRANOPYRAZOLES USING LANTHANUM FERRITE AS EFFICIENT AND REUSABLE HETEROGENEOUS CATALYST

Chandrashekhar A. Ladole*, Nagesh R. Nahate, Abdul Wajid

ABSTRACT

Recent applications of ferrites have received considerable attention in the field of heterogeneous catalyst and actively participated in the development of greener reaction protocols for providing a suitable support. Lanthanum ferrite as efficient and reusable heterogeneous catalyst were found to be efficient for the synthesis of pyranopyrazoles by a four-component reaction of a mixture of hydrazine hydrate, ethyl acetoacetate, aldehydes and malononitrile under solvent free condition. The catalyst was characterized by XRD and FT-IR studies. The advantages of these protocols are its greenness with respect to short reaction time, mild reaction conditions, operational simplicity and high yields. Ferrite catalysts can be easily recovered from reaction systems and reused up to several runs almost without loss of catalytic activity. Synthesized compounds were confirmed by using FTIR, 1H & 13C NMR spectroscopic data and melting points compared with reported values.

Keywords: Pyranopyrazoles, lanthanum ferrite, heterogeneous catalyst, multicomponent reaction.