EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ROSMARINIC ACID AMELIORATES MEMORY DETERIORATION AND OXIDATIVE STRESS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Vinayaka Shahavi* and Rahul Somani

ABSTRACT

Diabetes induced memory dysfunction is found to be equivalent with Alzheimer’s disease, disturbing normal physical, mental and social life of patients. Rosmarinic acid is flavonoid known to have pharmacological action against diabetes and diabetic complications. However, its effect in diabetic induced memory dysfunction and related oxidative stress has not been evaluated. Hence, present study was designed, conducted and analyzed for assessment of diabetes induced memory deterioration and oxidative changes in various parts of brain in Streptozotocin (STZ) induced diabetic rats. Diabetes was induced by streptozotocin (60 mg/kg, i.p.) in rats. After confirmation of diabetes treatment of Rosmarinic acid (12.5, 25, 50 mg/kg, p.o.) was started in separate group of animals. After 30 days diabetic rats showed significant memory deficits and also increased cholinesterase and MDA levels and depleted reduced glutathione levels in hippocampus and cerebral cortex. Moreover, chronic treatment of Rosmarinic acid had substantial influence on memory deficit in diabetic rats. Additionally, treatment of Rosmarinic acid significantly decreases blood glucose levels and MDA levels. Further, GSH levels found to be elevated in rosmarinic acid in diabetic rats. Also, cholinesterase levels are reduced which found to be elevated in diabetic rats. The result obtained from study points that treatment with Rosmarinic acid in diabetic rats ameliorates memory loss and oxidative stress.

Keywords: Rosmarinic acid, Diabetes, Memory dysfunction, Acetylcholinesterase, oxidative stress, Novel object recognition test.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia