EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

PREPARATION, CHARACTERISATION AND IN-VITRO RELEASE OF ANTI-CANCER ACTIVITY OF MWCNTS FUNCTIONALIZED WITH CARBOXYLIC GROUP

Dr. Hemalatha K. P.*, Dr. Suresh V. Kulkarni and Dr. P. Ashok Kumar

ABSTRACT

Functionalized carbon nanotubes developed by different functionalization processes, Functionalized CNTs possess the versatileness to act as composite to deliver the anticancer drugs. Viable effects and release of anticancer drug by preparing new neoplasia targeting drug delivery system by loading Irinotecan to MWCNTs that can implement essential challenges in the cancer treatment. Pristine MWCNTs are subjected to covalent functionalization by different methods to obtain consistent and steady dispersion of MWCNTs. Irinotecan complexed with functionalized MWCNTs evaluated by different methods such as SEM, FT-IR, TEM, TGA, Particle size analysis, Zeta potential, Drug entrapment efficiency, and Drug release studies. SEM AND TEM studies shows drug was well complexed to the MWCNTs. TGA results shows the Purity of MWCNTs, in vitro drug release analysed by statistical method, preparation of MWCNTs-Irinotecan complex is easy, commodious and come up with better development. Neoplasia drug containing Irinotecan may improve drug release and lessen the side effects.

Keywords: MWCNTs, Neoplasia, Nanoparticles, ANOVA. Taguchi method, Orthogonal Array.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia