PREPARATION, CHARACTERISATION AND IN-VITRO RELEASE OF ANTI-CANCER ACTIVITY OF MWCNTS FUNCTIONALIZED WITH CARBOXYLIC GROUP

Dr. Hemalatha K. P.*, Dr. Suresh V. Kulkarni and Dr. P. Ashok Kumar

ABSTRACT

Functionalized carbon nanotubes developed by different functionalization processes, Functionalized CNTs possess the versatileness to act as composite to deliver the anticancer drugs. Viable effects and release of anticancer drug by preparing new neoplasia targeting drug delivery system by loading Irinotecan to MWCNTs that can implement essential challenges in the cancer treatment. Pristine MWCNTs are subjected to covalent functionalization by different methods to obtain consistent and steady dispersion of MWCNTs. Irinotecan complexed with functionalized MWCNTs evaluated by different methods such as SEM, FT-IR, TEM, TGA, Particle size analysis, Zeta potential, Drug entrapment efficiency, and Drug release studies. SEM AND TEM studies shows drug was well complexed to the MWCNTs. TGA results shows the Purity of MWCNTs, in vitro drug release analysed by statistical method, preparation of MWCNTs-Irinotecan complex is easy, commodious and come up with better development. Neoplasia drug containing Irinotecan may improve drug release and lessen the side effects.

Keywords: MWCNTs, Neoplasia, Nanoparticles, ANOVA. Taguchi method, Orthogonal Array.