SCOPE OF CELL SHEET ENGINEERING IN PERIODONTICS – A NARRATIVE REVIEW
*Dr. Anusha D., Dr. Suchetha Aghanashini, Dr. Sapna Nadiger, Dr. Darshan Basavaraj Mundinamane, Dr. Apoorva Sokke Mallikarjunappa and Dr. Vinodhini
ABSTRACT
Tissue engineering including stem cell therapy is an emerging technique used for the regeneration of lost tissues in Medicine and Dentistry. Tissue engineering aims to engineer tissues by selecting optimal concentration of cells which acts as biological mediators and selectively enhance the chances of increase in cell matrix in periodontal defects. It helps in regeneration but has drawbacks such as isolating the correct type of cells and preparing a conducive environment for their growth. To overcome the limitations of present-day regeneration techniques, cell sheet engineering is gaining popularity. Cell sheet engineering offer several advantages over conventional stem cell engineering such as avoiding host inflammatory response, creation of extracellular matrix with intact cell-to-cell junctions, and escaping enzymatic degradation as these are thermo-responsive. Cell sheets appear to have a promising role in periodontics due to their ability to regenerate a variety of tissues such as gingiva, enamel, dental pulp, periodontal ligaments cells, cementum, alveolar bone, peri-implant tissue, and sections of the temporomandibular joint. In this review, tissue reorganization by using cell sheet engineering will be discussed along with sources of cell sheets, steps in preparation, and types of cell sheets both used in-vivo/in-vitro studies.
Keywords: Periodontics, Regeneration, Stem Cells.
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