EVALUATION OF ANTI-TUBERCULAR ACTIVITY OF SOME 2-PHENYL OXAZOLINE DERIVATIVES
V. Niraimathi* and K. Sudhakar
A series of 2-phenyl oxazolone derivatives were synthesized by condensation of aldehydes with N-benzoyl glycine in the presence of sodium acetate and acetic anhydride. Reacting the various oxazolone derivatives with isoniazid in presence of methanol yields various Schiff’s bases of oxazoline derivatives. The synthesis and characterization of 2-phenyl oxazoline derivatives has been published in WJPPS journal. The synthesized compounds were screened for In-vitro antitubercular activity by microplate Alamar Blue assay (MABA) method. The synthesized compounds were shown to exhibit antitubercular activity.
Keywords: Antitubercular activity.
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