FAMILIAL NASOPHARYNGEAL CARCINOMA: A CASE REPORT
Gamal Abdul Hamid* and Rasha Abbas
ABSTRACT
Background: The main risk factor for the development of nasopharyngeal carcinoma (NPC) is Epstein-Barr virus (EBV) infection. NPC is rare among Yemeni people while it is common among people of Chinese or some Middle Eastern ethnicity. Of the three histological types, the most globally diffused is the type III or undifferentiated carcinoma. We present a three cases of NPC which occurred in Yemeni brother and sister and cousin aunt's daughter. Case presentation and clinical discussion: We present the three cases report with NPC. The significant features are diagnosed in the same period with identical histology; therefore, the prognoses may be similar. Environmental factors could not be addressed in these cases because they shared the same background, and at the same time, they had no potential known contributing factors. Individuals with FH+ of NPC who had undergone EBV-directed investigations, with no restriction in the testing methods or analytic techniques. Conclusions: Even if it is rare, NPC can occur among Yemeni patients. EBV-DNA test is useful for diagnosis and post-treatment follow-up.
Keywords: Nasopharyngeal carcinoma, Epstein-Barr virus, Yemen, Lymph nodes.
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